The Importance of RSO2 Monitoring

Oct 13, 2025 by talynt.org 53 views

Comparison of RSO2 Changes in Midazolam Sedation and Post-Craniotomy Propofol at ICU H. Adam Malik RSUP

Introduction

Cerebral Regional Oxygen Saturation (RSO2) is a crucial indicator that reflects tissue perfusion in the brain. A decline in RSO2 can indicate the presence of cognitive dysfunction and affect the length of the inpatient period of patients in the hospital. In the context of post-operation care, sedative drugs such as midazolam and propofol are often used to calm patients. Both are known to reduce cerebral blood flow by reducing the rate of oxygen metabolism in the brain. This article aims to analyze the comparison of RSO2 changes after midazolam and propofol giving in post-craniotomy patients treated at ICU H. Adam Malik RSUP Medan.

The Importance of RSO2 Monitoring

RSO2 monitoring is essential in post-operation care to ensure optimal recovery and prevent cognitive dysfunction. A decline in RSO2 can indicate inadequate tissue perfusion, which can lead to brain damage and prolonged hospital stays. Therefore, it is crucial to monitor RSO2 levels in patients undergoing craniotomy procedures.

Research Methods

This research was conducted as a Randomized Control Trial study. Patients were divided into two groups: The first group received midazolam with an initial dose of 0.05 mg/kg followed by a maintenance dose of 0.02 - 0.10 mg/kg/hour, while the second group received propofol at a dose of 0.3 - 3 mg/kg/hour. The target for the two groups was the rass value between 0 to -2. The data collected was then analyzed using the t-test is not paired.

Research Results

The results of the analysis show that there is no significant difference in the characteristic data between the two groups, which means there are no factors that affect the parameters that are assessed. However, when analyzing RSO2 and RASS, there are statistically significant differences in the left and right RSO2 (p <0.001), although no significant differences are found in RASS (P> 0.05) between each group at each measurement time.

Further analysis revealed that there was no significant difference in changes in RSO2 both left and right (P> 0.05), but there were significant differences in RASS (P <0.001) at each measurement time. This indicates that although there are variations in RSO2, the anxiety response or the level of consciousness of the patient measured using RASS underwent significant changes.

Comparison of RSO2 Changes

The results of the study show that there is no significant change in RSO2 right and left, as well as the value of RASS after midazolam and propofol giving in post-craniotomy patients in ICU H. Adam Malik RSUP Medan. This finding shows that both sedative drugs have a similar impact on brain tissue perfusion in patients undergoing craniotomy procedures, although changes in RASS values indicate that patient awareness can vary depending on the sedation given.

Conclusion

Based on the results of the study, it can be concluded that there was no significant change in RSO2 right and left, as well as the value of RASS after midazolam and propofol giving in post-craniotomy patients in ICU H. Adam Malik RSUP Medan. This finding shows that both sedative drugs have a similar impact on brain tissue perfusion in patients undergoing craniotomy procedures, although changes in RASS values indicate that patient awareness can vary depending on the sedation given.

Implications for Clinical Practice

The results of this study have implications for clinical practice in the management of post-operation patients. The findings suggest that both midazolam and propofol can be used as sedative drugs in post-craniotomy patients, although the level of consciousness and anxiety response may vary depending on the sedation given. Therefore, it is essential to monitor RSO2 and RASS levels in a sustainable manner to ensure optimal recovery and prevent cognitive dysfunction.

Limitations of the Study

This study has several limitations. The sample size was relatively small, and the study was conducted in a single ICU setting. Therefore, the results may not be generalizable to other populations or settings. Additionally, the study only compared two sedative drugs, and the effects of other sedative drugs on RSO2 and RASS levels are not known.

Future Directions

Future studies should aim to investigate the effects of other sedative drugs on RSO2 and RASS levels in post-craniotomy patients. Additionally, studies should aim to investigate the effects of different sedation protocols on RSO2 and RASS levels in post-craniotomy patients. This will provide more information on the optimal management of post-operation patients and prevent cognitive dysfunction.

References

[List of references cited in the study]

Appendix

[Appendix materials, including raw data and additional figures and tables]

Abstract

This study aimed to compare the effects of midazolam and propofol on RSO2 and RASS levels in post-craniotomy patients. The results show that there is no significant change in RSO2 right and left, as well as the value of RASS after midazolam and propofol giving in post-craniotomy patients in ICU H. Adam Malik RSUP Medan. This finding shows that both sedative drugs have a similar impact on brain tissue perfusion in patients undergoing craniotomy procedures, although changes in RASS values indicate that patient awareness can vary depending on the sedation given.
Q&A: Comparison of RSO2 Changes in Midazolam Sedation and Post-Craniotomy Propofol at ICU H. Adam Malik RSUP

Frequently Asked Questions

We have received many questions from readers regarding our recent study on the comparison of RSO2 changes in midazolam sedation and post-craniotomy propofol at ICU H. Adam Malik RSUP. Below are some of the most frequently asked questions and our responses.

Q: What is RSO2 and why is it important?

A: RSO2 stands for Cerebral Regional Oxygen Saturation, which is a measure of the oxygen saturation in the brain tissue. It is an important indicator of brain tissue perfusion and is used to monitor the adequacy of cerebral oxygenation.

Q: What are the differences between midazolam and propofol?

A: Midazolam and propofol are both sedative drugs used to calm patients during medical procedures. However, they have different mechanisms of action and effects on the body. Midazolam is a benzodiazepine that works by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, while propofol is a non-benzodiazepine sedative that works by inhibiting the activity of the neurotransmitter acetylcholine in the brain.

Q: What were the results of the study?

A: The results of the study showed that there was no significant change in RSO2 right and left, as well as the value of RASS after midazolam and propofol giving in post-craniotomy patients in ICU H. Adam Malik RSUP Medan. This finding shows that both sedative drugs have a similar impact on brain tissue perfusion in patients undergoing craniotomy procedures, although changes in RASS values indicate that patient awareness can vary depending on the sedation given.

Q: What are the implications of the study for clinical practice?

A: The results of the study have implications for clinical practice in the management of post-operation patients. The findings suggest that both midazolam and propofol can be used as sedative drugs in post-craniotomy patients, although the level of consciousness and anxiety response may vary depending on the sedation given. Therefore, it is essential to monitor RSO2 and RASS levels in a sustainable manner to ensure optimal recovery and prevent cognitive dysfunction.

Q: What are the limitations of the study?

A: The study has several limitations. The sample size was relatively small, and the study was conducted in a single ICU setting. Therefore, the results may not be generalizable to other populations or settings. Additionally, the study only compared two sedative drugs, and the effects of other sedative drugs on RSO2 and RASS levels are not known.

Q: What are the future directions for research?

A: Future studies should aim to investigate the effects of other sedative drugs on RSO2 and RASS levels in post-craniotomy patients. Additionally, studies should aim to investigate the effects of different sedation protocols on RSO2 and RASS levels in post-craniotomy patients. This will provide more information on the optimal management of post-operation patients and prevent cognitive dysfunction.

Q: How can readers access the full study?

A: The full study is available online through our website. Readers can access the study by clicking on the link provided.

Q: Can readers contact the authors for further information?

A: Yes, readers can contact the authors for further information. Please email us at [insert email address] with any questions or comments.

Conclusion

We hope that this Q&A article has provided readers with a better understanding of the study and its implications for clinical practice. If you have any further questions or comments, please do not hesitate to contact us.